GARDP and Bugworks join forces to accelerate development of a novel antibiotic for bacterial infections
New Delhi: The Global Antitoxin Research & Minutiae Partnership (GARDP) is joining forces with Bugworks Research, a clinical-stage biopharmaceutical visitor with research and minutiae facilities in Bangalore, India, to slide the minutiae of a new broad-spectrum antitoxin recipe aimed at treating serious infections caused by multidrug-resistant bacteria.
The recipe stuff ripened by Bugworks, BWC0977, is aimed at treating patients with serious bacterial infections in both hair-trigger superintendency and polity settings. BWC0977 has the potential to treat infections that are rhadamanthine progressively difficult to treat due to the increase of antimicrobial resistance (AMR) in pathogens, such as Acinetobacter baumannii and Klebsiella pneumoniae. These pathogens can rationalization hospital-associated infections, such as pneumonia, bloodstream infections, meningitis, and urinary tract infections.
“Since 2019, we have been pursuit with interest the minutiae of BWC0977 as a potential treatment for drug-resistant infections caused by the most harmful and mortiferous yes-man on the WHO priority pathogens list,” said Dr Manica Balasegaram, GARDP’s Executive Director. “We are delighted to be worldly-wise to slide the minutiae of this promising antitoxin compound, by supporting clinical and pharmaceutical minutiae activities, with the hope of getting it to patients where it is most needed.”
This windfall has been supported by CARB-X since 2017, through optimization and preclinical minutiae and into first-in-human clinical studies.
GARDP and Bugworks have signed a term sheet to initiate this collaboration, with the goal of formalizing it through a collaboration agreement by end of the year.
According to the term sheet, GARDP would provide resources and funding for up to US$20 million to ensure a robust minutiae programme for BWC0977. It would work with Bugworks to whop BWC0977 through Phase II and Phase III studies and support its pharmaceutical development. The funds would be disbursed based on the victory of key milestones aligned with minutiae steps and GARDP’s public health objectives.
“We are thrilled to strengthen our ongoing partnership with GARDP to slide the clinical minutiae of BWC0977 and unhook a truly differentiated broad-spectrum drug that can tackle the toughest drug-resistant superbugs,” said Dr Anand Anandkumar, co-founder and CEO of Bugworks. “By leveraging GARDP’s unique global AMR network and clinical minutiae expertise, we aim to unzip our goal of ‘Go to Globe’, ensuring equitable wangle to this drug to patients wideness the planet. The strong support enabled by CARB-X has primed Bugworks’ collaboration with GARDP.”
As part of the intended collaboration, GARDP would work with Bugworks on a minutiae and commercialization project for the compound, whereby Bugworks would launch it in the European Union, US, Japan, China, directly or through sublicensees, and GARDP would obtain manufacturing rights and commercialization rights in a total of 148 countries, including nearly all low and middle-income countries.
One of the priorities for Bugworks and GARDP is to work closely to ensure rapid wangle and towardly use of this compound, once approved, in India and South Africa, and in other high-burden countries where BWC0977 could have a significant public health impact.
The phase I trial of BWC0977 is stuff conducted in Australia, with funding and technical support from CARB-X. “Bugworks was the second visitor to wield for funding from CARB-X, when in 2016, and we have velocious BWC0977 all the way from lead optimization, through preclinical minutiae and into first-in-human clinical studies,” said Kevin Outterson, Executive Director of CARB-X and Austin B. Fletcher Professor at Boston University School of Law. “We are grateful to GARDP for collaborating with Bugworks on the wide minutiae of BWC0977. This is aligned with the global stewardship and wangle commitments which we ask every CARB-X recipient to make when they join our portfolio.”
In 2020, GARDP and Bugworks signed a Memorandum of Understanding (MOU) to explore antitoxin minutiae to tackle serious bacterial infections in high-burden countries. In 2022, GARDP provided support for a cardiac safety study embedded in the ongoing first-in-human study that will provide an early towage of potential cardiovascular risk of BWC0977.
Serious bacterial infections occurring in hospitals and other healthcare settings often lead to sepsis and death without prompt and constructive treatment. Currently, the most difficult-to-treat infections are caused by Gram-negative bacteria, which have wilt resistant to most misogynist antitoxin treatments. Minutiae of new antibiotics that are constructive versus such infections is hair-trigger to counter the public health slipperiness in hospitals everywhere, but expressly in countries with a upper undersong of AMR.
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